CharacteristicsA natural replicate of autologous bone, Gen-Os® conserves the same intimate structures(1) (matrix and porous form) and presents highly osteoconductive properties(2,3).
It is biocompatible and bioavailable, as recognized by tests made according to the ISO 10993 method conducted at Eurofins Biolab.
Gen-Os® is gradually resorbable and provides support in bone neoformation helping to preserve the original graft shape and volume(4). Moreover, thanks to its collagen content, the product facilitates blood clotting and the subsequent invasion of repairing and regenerative cells, favouring restitutio ad integrum of missing bone. Because of its marked hydrophilia(5), it can function as a carrier for selected medications and drugs(6) and it is ideal to mix with GFs(7).HandlingGen-Os® must always be hydrated and thoroughly mixed with either a few drops of sterile physiological solution (or patient’s blood) to activate its collagen matrix and to enhance its adhesivity or with TSV Gel to increase graft stability in not self-contained defects. If necessary, it can as well be mixed with the drug selected for surgery.Clinical informationGen-Os®, a cortico-cancellous bone mix, has been the first product developed with the Tecnoss® innovative biotechnology and, due to its universal use, still is today the most demanded from the market. Gen-Os® has been successfully used and documented for alveolar ridge preservation(8) in combination with Evolution membranes: the application of this biomaterial limits the alveolar ridge width reduction that would naturally occur with spontaneous healing, preserving thus the alveolar ridge volume and allowing a correct second stage implant placement(9).
Gen-Os® has been used for lateral access maxillary sinus lift(3) and dehiscence regeneration(10), always in association with Evolution membranes.
Gen-Os® has been documented in periodontal regeneration of deep infrabony defects(11). Due to its collagen content, once hydrated Gen-Os® becomes very sticky and hydrophilic(5): it combines therefore extremely well with blood and is very stable once applied into the grafting site. Its cortico-cancellous composition allows a progressive resorption of osteoclastic type, with in parallel a similar rate of new bone formation(2): these unique properties allow a very good graft volume preservation, a healthy and well vascularized new bony tissue and, ultimately, a successful implant rehabilitation. Gen-Os® is in fact able to boost vascularization: in vitro(12) assays proved an increase in the secretion of VEGF by periodontal ligament cells (PDL) in the presence of Gen-Os®, as well as an enhanced proliferation of endothelial cells.
- Tissue origin :
Cortico-cancellous heterologous bone mix
- Tissue collagen :
- Physical form :
Slightly radiopaque granules
- Composition :
100% granulated mix
- Granulometry :
- Re-entry time :
4/5 months, depending on grafting site characteristics
- Packaging :
Vial: 0.25 g, 0.5 g, 1.0 g, 2.0 g
- Product codes :
M1052FS | 1 Vial | 0.25 g | Porcine
M1052FE | 1 Vial | 0.25 g | Equine
M1005FS | 1 Vial | 0.5 g | Porcine
M1005FE | 1 Vial | 0.5 g | Equine
M1010FS | 1 Vial | 1.0 g | Porcine
M1010FE | 1 Vial | 1.0 g | Equine
M1020FS | 1 Vial | 2.0 g | Porcine
M1020FE | 1 Vial | 2.0 g | Equine
M0210FS | 1 Vial | 1.0 g | Porcine
M0220FS | 1 Vial | 2.0 g | Porcine